Xenical - Roche, Greece orlistat XENICAL is a prescription weight-control medication useful for the long-term treatment of significant obesity. XENICAL can also help to improve risk factors, such as high blood pressure, high cholesterol and high blood sugar which, if not treated, could lead to other diseases such as hypertension and diabetes. Each XENICAL® capsule contains 120 mg of the active substance orlistat, which acts as a lipase inhibitor. XENICAL® is a weight loss medication that targets the absorption of fat in your body rather than suppressing your appetite. It is useful for long term use and has been shown to be effective for 1-2 years. Dietary fats are inhibited from being absorbed and this allows about 30% of the fat eaten in the meal to pass through the gut undigested. This helps you to reduce and maintain your weight, as well as to minimize any weight regain. Xenical is taken with each meal (three times daily). Your daily fat intake should be divided equally between these three meals so you will benefit from Xenical's actions. Your medicine should be swallowed with water.